Regarding sickle cell disease,
1. Mandible is usually spared from marrow expansion
2. On MR, irregular peripheral marrow enhancement around a nonenhancing center is more suggestive of osteomyelitis than infarction
3. Extramedullary haemopoitic tissue is shown as low signal on T1WI and high signal on T2WI
4. Hand-foot syndrome commonly affects infants
5. Sickle cell dactylitis is usually secondary to salmonella species
Answers: F, T, F, T, F
Notes:
Facial bones are usually spared from marrow expansion. Gadolinium enhanced MR demonstrates irregular peripheral marrow enhancement around a nonenhancing center in osteomyelitis. Extramedullary haemopoitic tissue is shown as intermediate signal on both T1WI and T2WI. Hand foot syndrome (sickle cell dactylitis) commonly affects between 6months and 2 years and is infarction of small bones of hands and feet.
Reference:
Ejindu VC et al. Musculoskeletal Manifestations of Sickle Cell Disease. RadioGraphics 2007;27:1005-1021
