Regarding CNS complications in paediatric oncology patients,
1. Intratumoral hemorrhage is most often seen with osteosarcoma metastases.
2. Children with Wilm's tumour are at high risk of reversible posterior encephalopathy.
3. L-Asparginase, which is used in treating ALL, is associated with sinus venous thrombosis.
4. Aspergillus is the most common lethal fungal infection.
5. The dissemination of tumore via CSG occurs more frequently in paediatric age than in adults.
Answers: T, T, T, T, T
Notes:
Sarcomas are most commonly associated with intratumoral bleed in brain and osteosarcoma is the most common sarcoma to matastasize to brain in paediatric age group. Reversible posterior encephalopathy is seen in children with elevated blood pressure (on steroids), Wilm's tumor and the children on Cyclosporin-A. L-Asperginase is associated with sinus venous thrombosis. Methotrexate is associated with reversible perventricular white matter signal abnormality. Aspergillus is the most common lethal fungal infection and usually appear as intermediate signal on T2 and PD sequences; they may not show enhancement, because of lack if inflammatory response.
Reference:
Chu WCW et al. Imaging findgins of paediatric oncology patients presenting with acute neurological symptoms. Clinical radiology (2003) 58:589-603
